Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol (July 26, 2006). doi:10.1152/ajpcell.00287.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
292/1/C82    most recent
00287.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mehta, P. K.
Right arrow Articles by Griendling, K. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mehta, P. K.
Right arrow Articles by Griendling, K. K.
Submitted on May 23, 2006
Accepted on July 18, 2006

Angiotensin II Cell Signaling: Physiological and Pathological Effects in the Cardiovascular System

Puja K. Mehta1 and Kathy K. Griendling1*

1 Dept of Medicine - Div of Cardiology, Emory University, Atlanta, Georgia, United States

* To whom correspondence should be addressed. E-mail: kgriend{at}emory.edu.

The renin-angiotensin system is a central component of the physiological and pathological responses of cardiovascular system. Its primary effector hormone, angiotensin II, mediates not only immediate physiological effects of vasoconstriction and blood pressure regulation, but mounting evidence implicates it in inflammation, endothelial dysfunction, atherosclerosis, hypertension, and congestive heart failure. The myriad effects of angiotensin II depend on time (acute vs. chronic) and on the cells/tissues upon which it acts. In addition to inducing G-protein and non-G protein related signaling pathways, angiotensin II, via AT1 receptors, carries out its functions via MAPK kinases (ERK 1/2, JNK, p38MAPK), receptor tyrosine kinases (PDGF, EGFR, IRS-1), and non-tyrosine receptor kinases (Src, Jak/Stat, FAK). AT1R-mediated NADPH oxidase activation leads to generation of reactive oxygen species, widely implicated in vascular inflammation and fibrosis. Angiotensin II also promotes the association of scaffolding proteins such as paxillin, talin, and p130Cas, leading to focal adhesion and extracellular matrix formation. These signaling cascades lead to contraction, smooth muscle cell growth and hypertrophy, and cell migration, events that contribute to normal vascular function and to disease progression. This review focuses on the structure and function of AT1 receptors and the major signaling mechanisms by which angiotensin influences cardiovascular physiology and pathology. Key Words: vascular smooth muscle, NAD(P)H oxidase, tyrosine and non-tyrosine receptor kinases, endothelial dysfunction, vascular disease.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
G. E. Striker, F. Praddaude, O. Alcazar, S. W. Cousins, and M. E. Marin-Castano
Regulation of angiotensin II receptors and extracellular matrix turnover in human retinal pigment epithelium: role of angiotensin II
Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1633 - C1646.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Di Zhang, A. N. D. Cat, C. Soukaseum, B. Escoubet, A. Cherfa, S. Messaoudi, C. Delcayre, J.-L. Samuel, and F. Jaisser
Cross-Talk Between Mineralocorticoid and Angiotensin II Signaling for Cardiac Remodeling
Hypertension, December 1, 2008; 52(6): 1060 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
U. Schmid, H. Stopper, F. Schweda, N. Queisser, and N. Schupp
Angiotensin II Induces DNA Damage in the Kidney
Cancer Res., November 15, 2008; 68(22): 9239 - 9246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. E. Gallagher, C. M. Ferrario, and E. A. Tallant
MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides
Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1169 - C1174.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Q. Sun, P. Yue, Z. Ying, A. J. Cardounel, R. D. Brook, R. Devlin, J.-S. Hwang, J. L. Zweier, L. C. Chen, and S. Rajagopalan
Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species-Mediated Activation of Rho/ROCK
Arterioscler. Thromb. Vasc. Biol., October 1, 2008; 28(10): 1760 - 1766.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S.-G. Wei, Y. Yu, Z.-H. Zhang, R. M. Weiss, and R. B. Felder
Mitogen-Activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats
Hypertension, October 1, 2008; 52(4): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
I. Papparella, G. Ceolotto, D. Montemurro, M. Antonello, S. Garbisa, G. Rossi, and A. Semplicini
Green Tea Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Rats by Modulating Reactive Oxygen Species Production and the Src/Epidermal Growth Factor Receptor/Akt Signaling Pathway
J. Nutr., September 1, 2008; 138(9): 1596 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. A. Banday and M. F. Lokhandwala
Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension
Am J Physiol Renal Physiol, September 1, 2008; 295(3): F698 - F706.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C.-X. Lin, N.-E. Rhaleb, X.-P. Yang, T.-D. Liao, M. A. D'Ambrosio, and O. A. Carretero
Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1253 - H1261.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. O. Deakin and C. E. Turner
Paxillin comes of age
J. Cell Sci., August 1, 2008; 121(15): 2435 - 2444.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Bagi, N. Erdei, and A. Koller
High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H835 - H841.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T.-D. Liao, X.-P. Yang, Y.-H. Liu, E. G. Shesely, M. A. Cavasin, W. A. Kuziel, P. J. Pagano, and O. A. Carretero
Role of Inflammation in the Development of Renal Damage and Dysfunction in Angiotensin II-Induced Hypertension
Hypertension, August 1, 2008; 52(2): 256 - 263.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Kim, L. Zhang, K. Peppel, J.-H. Wu, D. A. Zidar, L. Brian, S. M. DeWire, S. T. Exum, R. J. Lefkowitz, and N. J. Freedman
{beta}-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration
Circ. Res., July 3, 2008; 103(1): 70 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y.-M. Kang, Z.-H. Zhang, B. Xue, R. M. Weiss, and R. B. Felder
Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure
Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H227 - H236.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
W. J. Welch
Angiotensin II-Dependent Superoxide: Effects on Hypertension and Vascular Dysfunction
Hypertension, July 1, 2008; 52(1): 51 - 56.
[Full Text] [PDF]

Home page
 HypertensionHome page
K. M. Gauthier, D. X. Zhang, L. Cui, K. Nithipatikom, and W. B. Campbell
Angiotensin II Relaxations of Bovine Adrenal Cortical Arteries: Role of Angiotensin II Metabolites and Endothelial Nitric Oxide
Hypertension, July 1, 2008; 52(1): 150 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. L. Cook, R. N. Re, D. L. deHaro, J. M. Abadie, M. Peters, and J. Alam
The Trafficking Protein GABARAP Binds to and Enhances Plasma Membrane Expression and Function of the Angiotensin II Type 1 Receptor
Circ. Res., June 20, 2008; 102(12): 1539 - 1547.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
I. Imayama, T. Ichiki, D. Patton, K. Inanaga, R. Miyazaki, H. Ohtsubo, Q. Tian, K. Yano, and K. Sunagawa
Liver X Receptor Activator Downregulates Angiotensin II Type 1 Receptor Expression Through Dephosphorylation of Sp1
Hypertension, June 1, 2008; 51(6): 1631 - 1636.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Eguchi
Triple Twist Theory of Rho Inhibition by the Angiotensin II Type 2 Receptor
Circ. Res., May 23, 2008; 102(10): 1143 - 1145.
[Full Text] [PDF]

Home page
 CirculationHome page
P. Gratze, R. Dechend, C. Stocker, J.-K. Park, S. Feldt, E. Shagdarsuren, M. Wellner, F. Gueler, S. Rong, V. Gross, et al.
Novel Role for Inhibitor of Differentiation 2 in the Genesis of Angiotensin II-Induced Hypertension
Circulation, May 20, 2008; 117(20): 2645 - 2656.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. F. Giani, M. M. Gironacci, M. C. Munoz, D. Turyn, and F. P. Dominici
Angiotensin-(1-7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity
Exp Physiol, May 1, 2008; 93(5): 570 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. C. Li and J. L. Zhuo
Intracellular ANG II directly induces in vitro transcription of TGF-{beta}1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors
Am J Physiol Cell Physiol, April 1, 2008; 294(4): C1034 - C1045.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. Xiao, Z. Xu, X. Huang, L. D. Longo, S. Yang, and L. Zhang
Prenatal Gender-Related Nicotine Exposure Increases Blood Pressure Response to Angiotensin II in Adult Offspring
Hypertension, April 1, 2008; 51(4): 1239 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Letavernier, J. Perez, A. Bellocq, L. Mesnard, A. de Castro Keller, J.-P. Haymann, and L. Baud
Targeting the Calpain/Calpastatin System as a New Strategy to Prevent Cardiovascular Remodeling in Angiotensin II-Induced Hypertension
Circ. Res., March 28, 2008; 102(6): 720 - 728.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. S. Vasan, S. Demissie, M. Kimura, L. A. Cupples, N. Rifai, C. White, T. J. Wang, J. P. Gardner, X. Cao, E. J. Benjamin, et al.
Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System: The Framingham Heart Study
Circulation, March 4, 2008; 117(9): 1138 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. K. Doughan, D. G. Harrison, and S. I. Dikalov
Molecular Mechanisms of Angiotensin II-Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
Circ. Res., February 29, 2008; 102(4): 488 - 496.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Nobe, T. Yamazaki, T. Kumai, M. Okazaki, S. Iwai, T. Hashimoto, S. Kobayashi, K. Oguchi, and K. Honda
Alterations of Glucose-Dependent and -Independent Bladder Smooth Muscle Contraction in Spontaneously Hypertensive and Hyperlipidemic Rat
J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 631 - 642.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. E. Herbert, Y. Mistry, R. Hastings, T. Poolman, L. Niklason, and B. Williams
Angiotensin II-Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways
Circ. Res., February 1, 2008; 102(2): 201 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Rose, J. Bond, S. Tighe, M. J. Toth, T. L. Wellman, E. M. B. de Montiano, M. M. Lewinter, and K. M. Lounsbury
Genes overexpressed in cerebral arteries following salt-induced hypertensive disease are regulated by angiotensin II, JunB, and CREB
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H1075 - H1085.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Konigshoff, A. Wilhelm, A. Jahn, D. Sedding, O. V. Amarie, B. Eul, W. Seeger, L. Fink, A. Gunther, O. Eickelberg, et al.
The Angiotensin II Receptor 2 Is Expressed and Mediates Angiotensin II Signaling in Lung Fibrosis
Am. J. Respir. Cell Mol. Biol., December 1, 2007; 37(6): 640 - 650.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Mogi, M. Iwai, and M. Horiuchi
Emerging Concepts of Regulation of Angiotensin II Receptors: New Players and Targets for Traditional Receptors
Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2532 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. Cooling, P. Hunter, and E. J. Crampin
Modeling Hypertrophic IP3 Transients in the Cardiac Myocyte
Biophys. J., November 15, 2007; 93(10): 3421 - 3433.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
X. Xu, C.-H. Ha, C. Wong, W. Wang, A. Hausser, K. Pfizenmaier, E. N. Olson, T. A. McKinsey, and Z.-G. Jin
Angiotensin II Stimulates Protein Kinase D-Dependent Histone Deacetylase 5 Phosphorylation and Nuclear Export Leading to Vascular Smooth Muscle Cell Hypertrophy
Arterioscler. Thromb. Vasc. Biol., November 1, 2007; 27(11): 2355 - 2362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. M. Harris, H. I. Cohn, S. Pesant, R.-H. Zhou, and A. D. Eckhart
Vascular smooth muscle Gq signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3072 - H3079.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Hu, A. Dandapat, and J. L Mehta
Angiotensin II Induces Capillary Formation From Endothelial Cells Via the LOX-1 Dependent Redox-Sensitive Pathway
Hypertension, November 1, 2007; 50(5): 952 - 957.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
C. Aboa-Eboule, C. Brisson, E. Maunsell, B. Masse, R. Bourbonnais, M. Vezina, A. Milot, P. Theroux, and G. R. Dagenais
Job Strain and Risk of Acute Recurrent Coronary Heart Disease Events
JAMA, October 10, 2007; 298(14): 1652 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. Cooper, A. Whaley-Connell, J. Habibi, Y. Wei, G. Lastra, C. Manrique, S. Stas, and J. R. Sowers
Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2009 - H2023.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Hitomi, H. Kiyomoto, A. Nishiyama, T. Hara, K. Moriwaki, K. Kaifu, G. Ihara, Y. Fujita, T. Ugawa, and M. Kohno
Aldosterone Suppresses Insulin Signaling Via the Downregulation of Insulin Receptor Substrate-1 in Vascular Smooth Muscle Cells
Hypertension, October 1, 2007; 50(4): 750 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Yogi, G.E. Callera, A.C.I. Montezano, A.B. Aranha, R.C. Tostes, E.L. Schiffrin, and R.M. Touyz
Endothelin-1, but not Ang II, Activates MAP Kinases Through c-Src-Independent Ras-Raf-Dependent Pathways in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1960 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Sachse and G. Wolf
Angiotensin II Induced Reactive Oxygen Species and the Kidney
J. Am. Soc. Nephrol., September 1, 2007; 18(9): 2439 - 2446.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. Y. Oudit, Z. Kassiri, M. P. Patel, M. Chappell, J. Butany, P. H. Backx, R. G. Tsushima, J. W. Scholey, R. Khokha, and J. M. Penninger
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice
Cardiovasc Res, July 1, 2007; 75(1): 29 - 39.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. L. Reudelhuber, K. E. Bernstein, and P. Delafontaine
Is Angiotensin II a Direct Mediator of Left Ventricular Hypertrophy?: Time for Another Look
Hypertension, June 1, 2007; 49(6): 1196 - 1201.
[Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
J. L Zhuo and X. C Li
Review: Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2007; 8(1): 23 - 33.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.