| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Cell Physiology, Vol 259, Issue 1 C3-18, Copyright © 1990 by American Physiological Society
ARTICLES |
M. T. Nelson, J. B. Patlak, J. F. Worley and N. B. Standen
Department of Pharmacology, University of Vermont, Burlington 05405.
Resistance arteries exist in a maintained contracted state from which they can dilate or constrict depending on need. In many cases, these arteries constrict to membrane depolarization and dilate to membrane hyperpolarization and Ca-channel blockers. We discuss recent information on the regulation of arterial smooth muscle voltage-dependent Ca channels by membrane potential and vasoconstrictors and on the regulation of membrane potential and K channels by vasodilators. We show that voltage-dependent Ca channels in the steady state can be open and very sensitive to membrane potential changes in a range that occurs in resistance arteries with tone. Many synthetic and endogenous vasodilators act, at least in part, through membrane hyperpolarization caused by opening K channels. We discuss evidence that these vasodilators act on a common target, the ATP-sensitive K (KATP) channel that is inhibited by sulfonylurea drugs. We propose the following hypotheses that presently explain these findings: 1) arterial smooth muscle tone is regulated by membrane potential primarily through the voltage dependence of Ca channels; 2) many vasoconstrictors act, in part, by opening voltage-dependent Ca channels through membrane depolarization and activation by second messengers; and 3) many vasodilators work, in part, through membrane hyperpolarization caused by KATP channel activation.
This article has been cited by other articles:
|
|
 |
|
  C. P. Nelson, J. M. Willets, N. W. Davies, R. A. J. Challiss, and N. B. Standen Visualizing the temporal effects of vasoconstrictors on PKC translocation and Ca2+ signaling in single resistance arterial smooth muscle cells Am J Physiol Cell Physiol, December 1, 2008; 295(6): C1590 - C1601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Dick, I. N. Bratz, L. Borbouse, G. A. Payne, U. D. Dincer, J. D. Knudson, P. A. Rogers, and J. D. Tune Voltage-dependent K+ channels regulate the duration of reactive hyperemia in the canine coronary circulation Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2371 - H2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Smith, S. E. Brett, K. D. Luykenaar, S. L. Sandow, S. P. Marrelli, E. J. Vigmond, and D. G. Welsh KIR channels function as electrical amplifiers in rat vascular smooth muscle J. Physiol., February 15, 2008; 586(4): 1147 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Essin, A. Welling, F. Hofmann, F. C. Luft, M. Gollasch, and S. Moosmang Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells J. Physiol., October 1, 2007; 584(1): 205 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koide, P. L. Penar, B. I. Tranmer, and G. C. Wellman Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1750 - H1759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, G. D. Fink, and J. J. Galligan Increased sympathetic venoconstriction and reactivity to norepinephrine in mesenteric veins in anesthetized DOCA-salt hypertensive rats Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H160 - H168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zhang, H. H. Patel, F. Murray, C. V. Remillard, C. Schach, P. A. Thistlethwaite, Paul. A. Insel, and J. X.-J. Yuan Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1202 - L1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Isacson, Q. Lu, R. H. Karas, and D. H. Cox RACK1 is a BKCa channel binding protein Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1459 - C1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schach, M. Xu, O. Platoshyn, S. H. Keller, and J. X.-J. Yuan Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L685 - L698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Brekke, W. F. Jackson, and S. S. Segal Arteriolar smooth muscle Ca2+ dynamics during blood flow control in hamster cheek pouch J Appl Physiol, July 1, 2006; 101(1): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Resnik, J. Herron, R. Fu, D. D. Ivy, and D. N. Cornfield Oxygen tension modulates the expression of pulmonary vascular BKCa channel {alpha}- and beta-subunits Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L761 - L768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ledoux, M. E. Werner, J. E. Brayden, and M. T. Nelson Calcium-Activated Potassium Channels and the Regulation of Vascular Tone Physiology, February 1, 2006; 21(1): 69 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Rosenfeld, T. Roy, K. DeSpain, and B. E. Cox Large-Conductance Ca2+-Dependent K+ Channels Regulate Basal Uteroplacental Blood Flow in Ovine Pregnancy Reproductive Sciences, September 1, 2005; 12(6): 402 - 408. [Abstract] [PDF]
|
|
|
|
|
|
I. N. Bratz, G. M. Dick, L. D. Partridge, and N. L. Kanagy Reduced molecular expression of K+ channel proteins in vascular smooth muscle from rats made hypertensive with N{omega}-nitro-L-arginine Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1277 - H1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. Bratz, A. N. Swafford Jr., N. L. Kanagy, and G. M. Dick Reduced functional expression of K+ channels in vascular smooth muscle cells from rats made hypertensive with N{omega}-nitro-L-arginine Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1284 - H1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Loewen and G. W. Forsyth Structure and Function of CLCA Proteins Physiol Rev, July 1, 2005; 85(3): 1061 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Berra-Romani, M. P. Blaustein, and D. R. Matteson TTX-sensitive voltage-gated Na+ channels are expressed in mesenteric artery smooth muscle cells Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H137 - H145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Martinez-Lemus, T. Crow, M. J. Davis, and G. A. Meininger {alpha}v{beta}3- and {alpha}5{beta}1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H322 - H329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Reading, S. Earley, B. J. Waldron, D. G. Welsh, and J. E. Brayden TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2055 - H2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Swafford Jr., I. N. Bratz, J. D. Knudson, P. A. Rogers, J. M. Timmerman, J. D. Tune, and G. M. Dick C-reactive protein does not relax vascular smooth muscle: effects mediated by sodium azide in commercially available preparations Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1786 - H1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. H. Mauban, C. V. Remillard, and J. X.-J. Yuan Hypoxic pulmonary vasoconstriction: role of ion channels J Appl Physiol, January 1, 2005; 98(1): 415 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Bowles, K. K. Maddali, V. K. Ganjam, L. J. Rubin, D. L. Tharp, J. R. Turk, and C. L. Heaps Endogenous testosterone increases L-type Ca2+ channel expression in porcine coronary smooth muscle Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2091 - H2098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Auger, A. Beausejour, M. Brochu, and J. St-Louis Increased Na+ intake during gestation in rats is associated with enhanced vascular reactivity and alterations of K+ and Ca2+ function Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1848 - H1856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Imadojemu, K. Mooney, C. Hogeman, M. E.J. Lott, A. Kunselman, and L. I. Sinoway Extracellular Calcium and Vascular Responses After Forearm Ischemia Circulation, July 6, 2004; 110(1): 79 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Heaps, J. L. Parker, M. Sturek, and D. K. Bowles Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries J Appl Physiol, July 1, 2004; 97(1): 310 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, C. V. Remillard, I. Fantozzi, M. Mandegar, T. T. Sison, S. Zhang, E. Burg, and J. X.-J. Yuan Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L226 - L238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirasawa and J. N. Benoit Stretch-induced calcium sensitization of rat lymphatic smooth muscle Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2573 - H2577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Mokelke, Q. Hu, M. Song, L. Toro, H. K. Reddy, and M. Sturek Altered functional coupling of coronary K+ channels in diabetic dyslipidemic pigs is prevented by exercise J Appl Physiol, September 1, 2003; 95(3): 1179 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lamboley, A. Schuster, J.-L. Beny, and J.-J. Meister Recruitment of smooth muscle cells and arterial vasomotion Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H562 - H569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ross and W. M. Armstead Differential role of PTK and ERK MAPK in superoxide impairment of KATP and KCa channel cerebrovasodilation Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R149 - R154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Constable, G. W. Smith, G. E. Rottinghaus, M. E. Tumbleson, and W. M. Haschek Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2034 - H2044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Gasull, E. Ferrer, A. Llobet, A. Castellano, J. M. Nicolas, J. Pales, and A. Gual Cell Membrane Stretch Modulates the High-Conductance Ca2+-Activated K+ Channel in Bovine Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 706 - 714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Berggreen and K.J. Heyeraas Role of K+ATP Channels, Endothelin A Receptors, and Effect of Angiotensin II on Blood Flow in Oral Tissues J. Dent. Res., January 1, 2003; 82(1): 33 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Slish, D. G. Welsh, and J. E. Brayden Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2196 - H2201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. VanBavel, O. Sorop, D. Andreasen, M. Pfaffendorf, and B. L. Jensen Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2239 - H2243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Hampl, J. Bibova, Z. Stranak, X. Wu, E. D. Michelakis, K. Hashimoto, and S. L. Archer Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2440 - H2449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Damron, N. Kanaya, Y. Homma, S.-O. Kim, and P. A. Murray Role of PKC, tyrosine kinases, and Rho kinase in alpha -adrenoreceptor-mediated PASM contraction Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1051 - L1064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yaghi, S. Mehta, and D. G. McCormack Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia J Appl Physiol, September 1, 2002; 93(3): 957 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sweeney, Y. Yu, O. Platoshyn, S. Zhang, S. S. McDaniel, and J. X.-J. Yuan Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L144 - L155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Emerson, T. O. Neild, and S. S. Segal Conduction of hyperpolarization along hamster feed arteries: augmentation by acetylcholine Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H102 - H109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Strauss, R. Rosenthal, D. Dey, J. Beninde, G. Wollmann, H. Thieme, and M. Wiederholt Effects of Protein Kinase C on Delayed Rectifier K+ Channel Regulation by Tyrosine Kinase in Rat Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Lee, D. Poburko, K.-H. Kuo, C. Y. Seow, and C. van Breemen Ca2+ oscillations, gradients, and homeostasis in vascular smooth muscle Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1571 - H1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamazaki, T. Nagakawa, N. Hatakeyama, N. Shibuya, and T. A. Stekiel The Effects of Propofol on Neural and Endothelial Control of In Situ Rat Mesenteric Vascular Smooth Muscle Transmembrane Potentials Anesth. Analg., April 1, 2002; 94(4): 892 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Storme, T. A. Parker, J. P. Kinsella, R. L. Rairigh, and S. H. Abman Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L56 - L66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamakage, X. Chen, A. Kimura, S. Iwasaki, and A. Namiki The Repolarizing Effects of Volatile Anesthetics on Porcine Tracheal and Bronchial Smooth Muscle Cells Anesth. Analg., January 1, 2002; 94(1): 84 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Bowles Gender influences coronary L-type Ca2+ current and adaptation to exercise training in miniature swine J Appl Physiol, December 1, 2001; 91(6): 2503 - 2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X.-J. Yuan Oxygen-sensitive K+ channel(s): where and what? Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1345 - L1349. [Full Text] [PDF]
|
|
|
|
|
|
Y. Hayabuchi, N. B. Standen, and N. W. Davies Angiotensin II inhibits and alters kinetics of voltage-gated K+ channels of rat arterial smooth muscle Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2480 - H2489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. McDaniel, O. Platoshyn, Y. Yu, M. Sweeney, V. A. Miriel, V. A. Golovina, S. Krick, B. R. Lapp, J.-Y. Wang, and J. X.-J. Yuan Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells J Appl Physiol, November 1, 2001; 91(5): 2322 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Cribbs Vascular Smooth Muscle Calcium Channels: Could "T" Be a Target? Circ. Res., September 28, 2001; 89(7): 560 - 562. [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, O. Platoshyn, J. Zhang, S. Krick, Y. Zhao, L. J. Rubin, A. Rothman, and J. X.-J. Yuan c-Jun Decreases Voltage-Gated K+ Channel Activity in Pulmonary Artery Smooth Muscle Cells Circulation, September 25, 2001; 104(13): 1557 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Budel, A. Schuster, N. Stergiopoulos, J.-J. Meister, and J.-L. Beny Role of smooth muscle cells on endothelial cell cytosolic free calcium in porcine coronary arteries Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1156 - H1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Belohlavkova, J. Simak, A. Kokesova, O. Hnilickova, and V. Hampl Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels J Appl Physiol, August 1, 2001; 91(2): 755 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Jaggar Intravascular pressure regulates local and global Ca2+ signaling in cerebral artery smooth muscle cells Am J Physiol Cell Physiol, August 1, 2001; 281(2): C439 - C448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rosenfeld, D. N. Cornfield, and T. Roy Ca2+-activated K+ channels modulate basal and E2{beta}-induced rises in uterine blood flow in ovine pregnancy Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H422 - H431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Armstead Vasopressin-Induced Protein Kinase C-Dependent Superoxide Generation Contributes to ATP-Sensitive Potassium Channel but Not Calcium-Sensitive Potassium Channel Function Impairment After Brain Injury Stroke, June 1, 2001; 32(6): 1408 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. McDaniel, O. Platoshyn, J. Wang, Y. Yu, M. Sweeney, S. Krick, L. J. Rubin, and J. X.-J. Yuan Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L870 - L880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Petkov, T. J. Heppner, A. D. Bonev, G. M. Herrera, and M. T. Nelson Low levels of KATP channel activation decrease excitability and contractility of urinary bladder Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1427 - R1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Cox, K. Folander, and R. Swanson Differential Expression of Voltage-Gated K+ Channel Genes in Arteries From Spontaneously Hypertensive and Wistar-Kyoto Rats Hypertension, May 1, 2001; 37(5): 1315 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Rao, L. Li, V. A. Golovina, O. Platoshyn, E. D. Strauch, J. |
